Mechanics · Biofluidics · Living systems

Mechanics of Fluid Transport in Living Tissues

I investigate how pressure, deformation and tissue architecture shape fluid transport in living systems, from porous collagen matrices to engineered microvessels and tumour-on-chip models.

Research highlights

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Flow and mechanics in collagen matrices

Remodelling of the collagen matrix (red) by senescent fibroblasts (green).

Open-access article · Physical Review Applied ↗

Periodic actuation

Time-resolved transport driven by oscillatory mechanical forcing.

Read the preprint ↗

Multiphysics tumour transport simulation

Multiphysics modelling

Diffusion and convection in simplified tumour models.

Organ-on-chip

Multilevel epithelial culture in laser-cut PMMA devices embedded in collagen.

Pressure-dependent transport in microvessels

Microvascular transport

Pressure-dependent barrier transport in engineered microvessels.

Open-access article · iScience ↗

01 — Research

Flows reshape tissues.
Tissues redirect flows.

Biological tissues are permeated by water, macromolecules, cells and signalling factors. Their transport emerges from the coupling between pressure, deformation, microstructure and active biological processes.

My work combines fluid mechanics, poromechanics, microfabrication, quantitative imaging and biological models to connect tissue organisation with transport function.

Fluid–structure interactions

How pressure and deformation reorganise transport pathways.

Poromechanics of living matter

How porous biological matrices store, release and redistribute fluids.

Multiscale biofluidics

How microscopic transport mechanisms become tissue-scale function.

02 — Publications

Latest publications

The complete publication record is available on

Latest preprint

2026

Pulsatile pressure actuation enhances solute clearance in engineered vasculature through strain accumulation–release

Daniel Alcaide Martín, Aurélien Bancaud, Jean Cacheux and Yukiko T. Matsunaga · bioRxiv · Preprint

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Latest peer-reviewed publications

2025

Porohyperelastic modeling of collagen-gel responses to periodic pressure actuation shows that embedded senescent fibroblasts induce tissue softening associated with fibrous-network reorganization

Jean Cacheux, Thomas Quénan, Daniel Alcaide Martín, Jose Ordonez-Miranda, Laurent Jalabert et al. · Physical Review Applied

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2025

Intraluminal pressure triggers a rapid and persistent reinforcement of endothelial barriers

Aurélien Bancaud, Tadaaki Nakajima, Jun-Ichi Suehiro, Baptiste Alric, Florent Morfoisse et al. · Lab on a Chip

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2024

Protocol for fabricating and characterizing microvessel-on-a-chip for human umbilical vein endothelial cells

Jean Cacheux, Tadaaki Nakajima, Daniel Alcaide Martín, Takanori Sano, Kotaro Doi et al. · STAR Protocols

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2024

Laminin and hyaluronan supplementation of collagen hydrogels enhances endothelial function and tight junction expression on three-dimensional cylindrical microvessel-on-a-chip

Daniel Alcaide Martín, Baptiste Alric, Jean Cacheux, Shizuka Nakano, Kotaro Doi et al. · Biochemical and Biophysical Research Communications

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2023

Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport

Jean Cacheux, Aurélien Bancaud, Daniel Alcaide Martín, Jun-Ichi Suehiro, Yoshihiro Akimoto et al. · iScience

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03 — People

A cross-institutional team investigating poromechanics and transport in microphysiological systems, with applications to cancer biology and translational research.